MODIFICAR COLUMNA en Oracle:¿cómo verificar si una columna es anulable antes de configurarla?

Podrías hacer esto en PL/SQL:

declare
  l_nullable user_tab_columns.nullable%type;
begin
  select nullable into l_nullable
  from user_tab_columns
  where table_name = 'MYTABLE'
  and   column_name = 'MYCOLUMN';

  if l_nullable = 'N' then
    execute immediate 'alter table mytable modify (mycolumn null)';
  end if;
end;